منابع مشابه
Destabilizing role of cathepsin S in murine atherosclerotic plaques.
OBJECTIVE Lysosomal proteinases have been implicated in a number of pathologies associated with extracellular matrix breakdown. Therefore, we investigated the possibility that the lysosomal proteinase cathepsin S may be involved in atherosclerotic plaque destabilization. METHODS AND RESULTS Atherosclerotic plaques in the brachiocephalic arteries of fat-fed apolipoprotein E/cathepsin S double ...
متن کاملHuman liver cathepsin L.
Cathepsin L was purified to apparent homogeneity from human liver obtained post mortem. It was necessary to treat the homogenate at pH 4.2 and 37 degrees C to release active enzyme. The purification procedure involved ion-exchange chromatography on carboxymethyl-Sephadex and the Mono S column of a Pharmacia fast-protein-liquid-chromatography system. The enzyme was found to consist of two polype...
متن کاملAspirin inhibits human telomerase activation in unstable carotid plaques
The activation of telomerase in unstable plaques is an important factor in atherosclerosis, and may be predictive of the risk of cerebrovascular diseases. Human telomerase reverse transcriptase (hTERT) is a subunit of telomerase that is essential for telomerase activation. The aim of the present study was to investigate whether aspirin inhibits the activation of telomerase and hTERT in unstable...
متن کاملNovel candidate genes in unstable areas of human atherosclerotic plaques.
OBJECTIVE Comparison of gene expression in stable versus unstable atherosclerotic plaque may be confounded by interpatient variability. The aim of this study was to identify differences in gene expression between stable and unstable segments of plaque obtained from the same patient. METHODS AND RESULTS Human carotid endarterectomy specimens were segmented and macroscopically classified using ...
متن کاملExpression of cathepsin L in human tumors.
It has been proposed that proteases secreted by cancer cells facilitate tumor invasion and metastasis by degrading the components of extracellular membranes. The lysosomal cysteine protease cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells in culture. The secreted protease is potent in degrading collagen, laminin, elastin, and other structural protei...
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ژورنال
عنوان ژورنال: Archives of Medical Science - Atherosclerotic Diseases
سال: 2020
ISSN: 2451-0629
DOI: 10.5114/amsad.2020.95563